During the week of February 22, the Center for Middle East Policy (CMEP) at Brookings will host an international conference — bringing together leaders and experts from the region, the United States, and elsewhere in the world — to discuss the top priorities for the United States and the countries of the Middle East and North Africa. The conference, titled “The Middle East and the new U.S. administration,” marks the successful first year of CMEP’s “Sources of Middle East instability” project. This signature effort brings to bear the center’s expertise in regional geopolitics, deep understanding of key countries, and insight into U.S. foreign policymaking to reassess assumptions about the region and to offer a sound knowledge basis for future policy.